Symbol
Name
ID

Wfs1
wolframin ER transmembrane glycoprotein
MGI:1328355

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes	Diabetes mellitus	Type II diabetes mellitus	Hypothyroidism	Diabetes insipidus	Delayed puberty	Hypogonadism	Male hypogonadism
Disease(s) Associated with WFS1	Diabetes mellitus	Type II diabetes mellitus	Hypothyroidism	Diabetes insipidus	Delayed puberty	Hypogonadism	Male hypogonadism
autosomal dominant Wolfram syndrome
optic atrophy
type 1 diabetes mellitus
type 2 diabetes mellitus
Wolfram syndrome
Wolfram syndrome 1

Mouse Phenotypes

abnormal pancreatic islet morphology

decreased pancreatic beta cell mass

decreased pancreatic beta cell number

disorganized pancreatic islets

abnormal thyroid gland morphology

abnormal thyroid follicle morphology

abnormal seminiferous tubule morphology

abnormal seminiferous tubule epithelium morphology

decreased Sertoli cell number

increased glucagon secretion

abnormal pancreatic beta cell physiology

decreased insulin secretion

abnormal pancreas secretion

Availability

Mouse Genotype

Wfs1^tm1Koks/Wfs1^tm1Koks

Wfs1^tm1Yoka/Wfs1^tm1Yoka

Wfs1^tm1Perm/Wfs1^tm1Perm
Tg(Ins2-cre)23Herr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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